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Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan
《化学科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 386-406 doi: 10.1007/s11705-015-1533-3
关键词: process analytical technology (PAT) Fourier-transform infrared (FTIR) spectroscopy partial least squares (PLS) regression mouse IgG3 bioreactor cell culture process real time process monitoring
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
《医学前沿(英文)》 2008年 第2卷 第1期 页码 51-57 doi: 10.1007/s11684-008-0010-5
关键词: antitumor therapy occurrence implantation DNA vaccine SART3 DNA
《医学前沿(英文)》 2023年 第17卷 第3期 页码 549-561 doi: 10.1007/s11684-022-0965-7
关键词: pregnancy IgG glycome type I interferon systemic lupus erythematosus
《医学前沿(英文)》 2022年 第16卷 第6期 页码 919-931 doi: 10.1007/s11684-021-0918-6
关键词: preeclampsia recombinant protein diannexin microparticle NLRP3 inflammasome phosphatidylserin
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
《医学前沿(英文)》 2008年 第2卷 第2期 页码 195-199 doi: 10.1007/s11684-008-0037-7
关键词: chemotactic activity receptor uPA inhibitor F10 chemoattractant
《医学前沿(英文)》 2022年 第16卷 第3期 页码 378-388 doi: 10.1007/s11684-021-0840-y
关键词: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
High-level expression of recombinant IgG1 by CHO K1 platform
Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu
《化学科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 376-380 doi: 10.1007/s11705-015-1531-5
关键词: Chinese hamster ovary (CHO) monoclonal antibody IgG1 amplification cell line development
R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome
《医学前沿(英文)》 2022年 第16卷 第6期 页码 932-945 doi: 10.1007/s11684-022-0963-9
关键词: Gitelman syndrome mouse model compound heterozygous hypokalemia Slc12a3
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 112-120 doi: 10.1007/s11705-021-2075-5
关键词: fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients
《医学前沿(英文)》 doi: 10.1007/s11684-023-0997-7
IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险 Article
武志远, 郭政, 郑雨露, 王玉涛, 张海平, 潘慧颖, 李志伟, Lois Balmer, 李霞, 陶丽新, 郭秀花, 王嵬
《工程(英文)》 2023年 第26卷 第7期 页码 99-107 doi: 10.1016/j.eng.2022.12.004
亚临床动脉粥样硬化和代谢紊乱是心血管健康的重要风险因素,应用免疫球蛋白G(IgG)N-聚糖模式作为炎症指标表征其发病风险已有研究报道然而,对于IgG N-糖基谱在心血管疾病(CVD)风险分层中的能力仍然未知。本研究旨在利用IgG N-糖基标志物开发追踪心血管疾病风险的年龄指数。使用机器学习递归特征消除和惩罚回归算法逐步筛选特征糖基,并开发IgG N-糖基化心血管年龄(GlyCage)指数,以反映归因于心血管风险的与真实年龄间的偏差。因此,本研究开发的GlyCage指数利用IgG N-糖基谱追踪心血管健康水平。GlyCage和真实年龄之间的差距能够独立地表征心血管风险,提示IgG N-糖基化在心血管疾病的发病机制中起作用。
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 99-105 doi: 10.1007/s11783-013-0490-7
Molecular dynamic simulation on the conformation of mouse muscle type nAChR
Shengai SUN, Rilei YU, Yanhui ZHANG, Yanni LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第3期 页码 348-352 doi: 10.1007/s11705-009-0284-4
关键词: pentameric hydrophilic Tyr127 cryoelectron microscopic conformation
Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 330-335 doi: 10.1007/s11684-016-0459-6
The enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) is a histone-lysine N-methyltransferase enzyme that participates in DNA methylation. Ezh2 has also been reported to play crucial roles in stem cell proliferation and differentiation. However, the detailed expression profile of Ezh2 during mouse cochlear development has not been investigated. Here, we examined the spatiotemporal expression of Ezh2 in the cochlea during embryonic and postnatal development. Ezh2 expression began to be observed in the whole otocyst nuclei at embryonic day 9.5 (E9.5). At E12.5, Ezh2 was expressed in the nuclei of the cochlear prosensory epithelium. At E13.5 and E15.5, Ezh2 was expressed from the apical to the basal turns in the nuclei of the differentiating cochlear epithelium. At postnatal day (P) 0 and 7, the Ezh2 expression was located in the nuclei of the cochlear epithelium in all three turns and could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice. Our results provide the basic Ezh2 expression pattern and might be useful for further investigating the detailed role of Ezh2 during cochlear development.
关键词: polycomb repressive complex Ezh2 expression inner ear cochlea development
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
《医学前沿(英文)》 2009年 第3卷 第2期 页码 141-147 doi: 10.1007/s11684-009-0041-6
标题 作者 时间 类型 操作
Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared
Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan
期刊论文
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
期刊论文
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk betweenIgG sialylation and pDC functions
期刊论文
Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing
期刊论文
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
期刊论文
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein
期刊论文
High-level expression of recombinant IgG1 by CHO K1 platform
Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu
期刊论文
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
期刊论文
IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险
武志远, 郭政, 郑雨露, 王玉涛, 张海平, 潘慧颖, 李志伟, Lois Balmer, 李霞, 陶丽新, 郭秀花, 王嵬
期刊论文
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
期刊论文
Molecular dynamic simulation on the conformation of mouse muscle type nAChR
Shengai SUN, Rilei YU, Yanhui ZHANG, Yanni LI,
期刊论文